Board of Trustees

Stephan Ladisch, MD

Stephan Ladisch graduated from the University of Pennsylvania and completed his pediatric residency at Children’s Hospital of Boston. He first became interested in the histiocytoses during his fellowship in pediatric oncology at the National Cancer Institute, where he discovered an immunodeficiency syndrome associated with FEL (now known as a form of HLH). In 1978, he joined the faculty of the University of California, Los Angeles (UCLA), where he continued his research in histiocytosis and in cancer biology and has since been actively involved in developing histiocytosis clinical trials. He became Professor of Pediatrics in 1986, and in 1991, he was recruited to Children’s National Medical Center (CNMC) to direct and develop the new Center for Cancer and Transplantation Biology at the Children’s Research Institute (CRI). He has also served as CRI’s first Scientific Director (1998-2005) as Vice Chairman of the Department of Pediatrics, and is Program Director of the NICHD-funded Child Health Research Center at CNMC since 2000. He holds the Bosworth Chair in Cancer Biology and is Professor of Pediatrics, Biochemistry, and Molecular Biology at George Washington University (GWU).

Dr. Ladisch has an international reputation in pediatric oncology and in histiocytosis, and is the author of more than 150 peer-reviewed articles in the areas of histiocytosis, cancer biology and immunology, and pediatric oncology, and he is on the editorial board of several journals. He has trained numerous graduate students and postdoctoral fellows, many of whom have gone on to academic positions. He is a member of several academic societies, including the Society for Pediatric Research and the American Association for Cancer Research, and is a Fellow of the American Academy of Pediatrics. His training activities also include a major role in developing the multidisciplinary graduate student training program at GWU, where he served as Director of the Institute for Biomedical Sciences. He is a member of the National Institutes of Health College of Scientific Reviewers.

Dr. Ladisch’s laboratory focuses on membrane gangliosides, their synthesis and shedding, and their roles in cell signaling, tumor biology and immunology, as well as in some forms of childhood histiocytosis. His research has been funded by the National Institutes of Health since 1980. He is a founding member and past-president of the Histiocyte Society and former Chairman of the Board of Trustees of the Histiocytosis Association.

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