LCH Grants Awarded

Please click on a letter below to view an alphabetical list of LCH Grants awarded by the Histiocytosis Association.

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Accumulation of Misguided Lymphocytes and Dendritic Cells: A New Model for LCH
Carl E. Allen MD, PhD and Kenneth L. McClain MD, PhD
Texas Children’s Hospital/Baylor College of Medicine - Houston, Texas USA
Grant Awarded in: 2008

Analysis of Jagged2 Signaling in Langerahans Cell Histiocytosis
Caroline Hutter MD, PhD
Children's Cancer Resarch Institute/St. Anna Kinderspital - Vienna, Austria
Grant Awarded in: 2012

Analysis of T-cell Function in Langerhans Cell Histiocytosis
Kenneth L. McClain MD, PhD and Carl E. Allen MD, PhD
Texas Children's Hospital, Baylor College of Medicine - Houston, Texas USA
Grant Awarded in: 2006

Analysis of the Tumor Necrosis Factor Receptor Pathway in LCH
Manfred B. Lutz PhD and Jens Oliver Funk MD
University of Erlangen - Erlangen, Germany
Award Amount: $30,000
Grant Awarded in: 2001

Assesment of PTPN6 (SHP-1) in Langerhans Cell Line
Ichiro Murakami MD, PhD and Takashi Oka PhD
Tottori University - Yonago-shi, Japan
Grant Awarded in: 2009

Assessment of Risk Factor for the Development of Diabetes & Other Central Nervous System Abnormalities in LCH
Nicole Grois MD
St. Anna Children’s Hospital - Vienna, Austria
Award Amount: $30,000
Grant Awarded in: 2000

Association of HHV-8 with Langerhans Cell Histiocytosis
Frank Jenkins PhD
University of Pittsburgh Cancer Institute - Pittsburgh, Pennsylvania USA
Award Amount: $16,609
Grant Awarded in: 1999

Biologic Correlates of Response to Therapy in LCH
Kenneth McClain MD, PhD
Baylor College of Medicine - Houston, Texas USA
Total Amount of Award: $30,000
Grant Awarded in: 2002-2004

Biomarker Monitoring of Central Nervous System Disease in Langerhans Cell Histiocytosis
Jan-Inge Henter MD, PhD
Karolinska Institutet – Stockholm, Sweden
Grant Awarded in: 2007

Bone Marrow Involvement in Patients with Multi-System Langerhans Cell Histiocytosis
Michael Dworzak MD and Nicole Grois MD
St. Anna Children’s Hospital - Vienna, Austria
Award Amount: $10,000
Grant Awarded in: 1994

BRAF V600E-Drive Mouse Model of Langerhans Cell Histiocytosis
Gayane Badalian Very MD, PhD
Dana-Farber Cancer Institute - Boston, Massachusetts USA
Grant Awarded in: 2011

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Cell-Associated and Soluble Macrophage Mannose Receptor: A Potential New Marker for Langerhans Cell Histiocytosis
Siamon Gordon PhD
Sir Williams Dunn School of Pathology - Oxford, United Kingdom
Grant Awarded in: 1997-1998

Characterization of Cytokine Production by LCH Cells
Raymond Yu MD
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $10,000
Grant Awarded in: 1992

Characterization of the Presence and Activation of Growth Factors and Their Receptors in LCH Cells
Christian Nezelof MD (PI) and Sylvette Barbey PhD
Hospital Saint-Louis - Paris, France
Award Amount: $10,000
Grant Awarded in: 1993

Characterization of T-cells and Langerhans Cells in LCH
Eric Classen MD and Maarten Egeler MD
Sophia Children’s Hospital - Rotterdam, The Netherlands
Award Amount: $10,000
Grant Awarded in: 1994

Cigarette Smoking and TSLP in the Pathogenesis of Pulmonary LCH
Robert Vassallo MD
Pulmonary and Critical Care Medicine, Mayo Clinic - Rochester, Minnesota USA
Grant Awarded in: 2005

Cigarette Smoking Promotes Dendritic Cell Survival and Resistance to Apoptosis Through HEME-Oxygenase-1
Dependant Mechanisms

Robert Vassallo MD
Mayo Clinic - Rochester, Minnesota USA
Grant Awarded in: 2006

Clonality & Cytogenetic Abnormalities in Patients with Langerhans Cell Histiocytosis of Varying Clinical Severity
Tony Chu FRCP
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $10,000
Grant Awarded in: 1995

Comparative Genomic Hybridization in Langerhans Cell Histiocytosis
Mary Haag PhD
All Children’s Hospital - St. Petersburg, Florida USA
Award Amount: $10,000
Grant Awarded in: 1994

Cytokine Production in Langerhans Cell Histiocytoses
George Kannourakis MD, PhD
Royal Children’s Hospital - Victoria, Australia
Award Amount: $10,000
Grant Awarded in: 1993

Cytokines in Langerhans Cell Histiocytosis: A Molecular Biology Study
Pauline Chou MD
Children’s Memorial Hospital - Chicago, Illinois USA
Award Amount: $10,000
Grant Awarded in: 1992

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Design for a Mouse Model of Langerhans Cell Histiocytosis
Kenneth McClain MD, PhD
Texas Children’s Hospital - Houston, Texas USA
Award Amount: $30,000
Grant Awarded in: 1999

Determination of Clonality in Langerhans Cell Histiocytosis (LCH)
Cheryl Willman MD
University of New Mexico - Albuquerque, New Mexico USA
Award Amount: $40,000
Grant Awarded in: 1993

Development of a Mouse Xenograft Model to Examine the Localization, Binding & Killing of CD1a Positive Cells
by Monoclonal Antibodies & Single Chain Fvs

Samuel Murray
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $10,000
Grant Awarded in: 1994

Development of a Murine Model for LCH Using Binary Knock-in Mice
Frederic Geissmann MD, PhD
Necker-Enfants Malades Hospital - Paris, France
Grant Awarded in: 2005

Development of a Single Chain Monoclonal Antibody to CD1a for Immunoimaging and Treatment of Patients with
Langerhans Cell Histiocytosis
Tony Chu FRCP
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $22,755
Grant Awarded in: 1999

Dysregulation of Dendritic Cell Development in Langerhans Cell Histiocytosis
Matthew Collin, MD
Newcastle University - Newcastle upon Tyne, United Kingdom
Award Amount: $50,000
Grant Awarded in: 2013

Dysregulation of Dendritic Cell Development in Langerhans Cell Histiocytosis II: Langerin Induction and Comparative Gene Expression Studies
Matthew Collin, MD
Newcastle University - Newcastle Upon Tyne, United Kingdom
Award Amount: $50,000
Grant Awarded in: 2015

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Epidemiology Study of LCH in Children in a Special Population Group
Jonathan Ducore MD
University of California, Davis Medical Center - Davis, California USA
Award Amount: $5,500
Grant Awarded in: 2000

Evaluation of Thalidomide for Treatment of Resistant Langerhans Cell Histiocytosis
Kenneth McClain MD, PhD
Texas Children’s Hospital - Houston, Texas USA
Award Amount: $30,000
Grant Awarded in: 2001

Exploring CD8+ T cell-LCH-cell Interactions in Langerhans cell histiocytosis: A Three Center Study
Astrid van Halteren, PhD
Leiden University Medical Center, Leiden, Netherlands
Grant Awarded in: 2014

Exploring Coexisting Maternal Microchimeric Cells and Host T-cells in LCH Lesions
A.G.S. van Halteren PhD and R. Maarten Egeler MD, PhD
Leiden University Medical Center - Leiden, The Netherlands
Grant Awarded in: 2009

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Flow Cytometric and Secretomic Analysis of LCH Lesions
Matthew Collin MD
Institute of Cellular Medicine – Newcastle upon Tyne UK
Grant Awarded in: 2010

FLT3 Ligand in LCH
Anna Paluka MD, PhD
Baylor Institute for Immunology Research - Dallas, Texas USA
Total Amount of Award: $60,000 (paid over two years)
Grant Awarded in: 2002-2004

Focused Screening of Novel Therapies for HLH Using an Animal Model
Michael Jordan MD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2012

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Gene Expression in Langerhans Cell Histiocytosis
Kenneth L. McClain MD, PhD
Baylor College of Medicine, Texas Children's Cancer Center - Houston, Texas USA
Grant Awarded in: 2005

Gene Expression Strategy to Identifiy the Cell of Origin in Langerhans Cell Histiocytosis
Carl E. Allen MD, PhD
Texas Children’s Hospital – Houston, Texas USA
Grant Awarded in: 2010

Generation of Immortalized Cell Lines of Langerhans Cell and Langerhans Cell Histiocytosis Cells
Tony Chu FRCP
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $25,000 (paid over two years)
Grant Awarded in: 1995 and 1996

Genetic Characterization of Langerhans Cell Differentiation in LCH
Kelvin Lee MD
University of Miami School of Medicine - Miami, Florida USA
Grant Awarded in: 2005

Genome-Wide Detection of Possible Chromosomal Imbalances in LCH Lesional Cells Using BAC Microarrays
Nicola Elizabeth Annels MD
Leiden University Medical Center - Leiden, The Netherlands
Grant Awarded in: 2005

Genomic Array and Expression Analysis of Frequent Amplifications in CD1a+LCH Cells
Nicola Elizabeth Annels MD
Leiden University Medical Center - Leiden, The Netherlands
Grant Awarded in: 2006

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Histiocyte Society Clinical Trials Database System
 LCH-IV Treatment Protocol Study
LCH Study Reference Center - Vienna, Austria
Grant Awarded in: 2008

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center – Vienna, Austria
Grant Awarded in: 2010

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center – Vienna, Austria
Grant Awarded in: 2011

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center - Vienna, Austria
Grant Awarded in: 2012

Histiocyte Society Clinical Trials Database System LCH-IV Treatment Protocol Study
Histiocyte Society Executive Board
LCH Study Reference Center - Vienna, Austria
Grant Awarded in: 2013

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Identification of Specific T-cell Receptor: Rearrangements in LCH Lesions
Jack Gorski PhD
Blood Center of Southwest Wisconsin - Milwaukee, Wisconsin USA
Award Amount: $20,000
Grant Awarded in: 1993

Identifying Familial Associations in Langerhans Cell Histiocytosis Using the Utah Population Database
Mark Fluchel MD
Primary Children’s Hospital – Salt Lake City, Utah USA
Grant Awarded in: 2010

Improving Diagnostics of and Gaining Mechanistic Insights into Defects in Lymphocyte Cytotoxicity Underlying HLH
Yenan Bryceson PhD
Karolinska Institutet Center for Infectious Medicine - Stockholm, Sweden

Immune Dysregulation in Canine Langerhans Cell Histiocystosis; An Animal Model for the Human Disease
Peter Moore PhD
University of California, School of Veterinary Medicine - Davis, California USA
Award Amount: $20,000
Grant Awarded in: 1996

Innate T cells in Langerhan’s Cell Histiocytosis
Stuart Berzins, PhD
Federation University Australia - Ballarat, Victoria, Australia
Award Amount: $50,000
Grant Awarded in: 2016

Investigating Chemokine Receptor Usage as an Explanation for the Aberrant Behaviour of CD1a Cells in LCH
Nicola Annels MD
Leiden University Medical Center - Leiden, The Netherlands
Total Amount of Award: $60,000 (paid over two years)
Grant Awarded in: 2002-2004

Investigation Using DNS Microarrays of the Expression of Matrix Metalloproteinases in Normal and Langerhans Cells
Stephen Jolles PhD
National Institute for Medical Research - London, United Kingdom
Total Amount of Award: $30,000
Grant Awarded in: 2002-2004

Investigations of Immunotherapy of LCH Using Monoclonal Antibodies to CD1a
Tony Chu FRCP
Royal Post Graduate Medical School - London, United Kingdom
Award Amount: $10,000
Grant Awarded in: 1992

Investigation of Molecular Mechanisms Underlying LCH: Characterization of a Disease Specific DNA Library
Tony Chu FRCP
Hammersmith Hospital - London, United Kingdom
Total Amount of Award: $30,000
Grant Awarded in: 2002-2004

Investigation of Possible Associations of Histocompatibility and/or Tumor Necrosis Factor Types with Susceptibility to LCH or Particular Clinical Manifestations of this Disease
Marilyn Pollack PhD and Kenneth McClain MD, PhD
Texas Children’s Hospital - Houston, Texas USA
Award Amount: $20,000
Grant Awarded in: 1996

Isolation and Culture of Human Fetal Dendritic/Langerhans Cells
Ronald Jaffe MD
Children’s Hospital of Pittsburgh - Pittsburgh, Pennsylvania USA
Award Amount: $10,000
Grant Awarded in: 1992

Isolation, Identification, and Studies on the Biology of a Transmissible Agent Involved in the Causation of Langerhans Cell Histiocytosis: Implications for Future Treatment Strategies for Disseminated LCH
George Kannourakis PhD
Royal Children’s Hospital - Victoria, Australia
Award Amount: $72,000
Grant Awarded in: 1996

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Knock-In Mouse Model Mimicking Abnormal Langerhans Cell Trafficking in Langerhans Cell Histiocytosis
Barrett J. Rollins MD, PhD
Dana-Farber Cancer Institute, Harvard Medical School - Boston, Massachusetts USA
Grant Awarded in: 2008

Langerhans Cell Histiocytosis I & II Studies - North American and European Regional Studies
Stephan Ladisch MD; H. Stacy Nicholson MD; Helmut Gadner MD, FRCP
Children’s National Medical Center - Washington, District of Columbia USA
Award Amount: $40,000
Grant Awarded in: 1995

Langerhans Cell and Dendritic Cell Homeostasis in Human Skin
Matthew Collin MD
Newcastle University - Newcastle upon Tyne, United Kingdom
Grant Awarded in: 2006

LCH-II Clinical Trial
Helmut Gadner MD, FRCP (PI) and Nicole Grois MD
St. Anna Children’s Hospital - Vienna, Austria
Award Amount: $25,000
Grant Awarded in: 2000

LCH-III Clinical Trial
Nicole Grois MD
St. Anna Children’s Hospital - Vienna, Austria
Award Amount: $30,000
Grant Awarded in: 2001

LCH-III Clinical Trial
Nicole Grois MD
St. Anna Children’s Hospital - Vienna, Austria
Total Amount of Award: $45,000 (paid over two years)
Grant Awarded in: 2002-2004

LCH-III Clinical Trials
Nicole Grois MD
St. Anna's Children's Hospital - Vienna, Austria
Grant Awarded in: 2006

LCH-IV Clinical Trial – Stratum I Patient Registration Reimbursement for North American Institutions
Carlos Rodriguez-Galindo, MD
St. Jude Children's Research Hospital - Memphis, Tennessee USA
Amount Awarded: $50,000 per year for 2 years
Grant Awarded in: 2015 - 2016

Lymphocyte Trafficking in Langerhans Cell Histiocytosis
Kenneth McClain MD, PhD and Carl Allen MD, PhD
Texas Children’s Cancer Center/Hematology Service - Houston, Texas USA
Grant Awarded in: 2007

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M1 Versus M2 Polarization of the Hemophagocyte: Insight into Biologic Function
Edward Behrens MD
The Children's Hospital of Philadelphia - Philadelphia, Pennsylvania, USA
Grant Awarded in: 2012

Mechanisms of IL-17A-Dependent Dendritic Cell Long-Term Survival and Fusion in Langerhans Cell Histiocytosis

Christine Delprat MD, PhD
INSERM – Lyon, France
Grant Awarded in: 2007

Molecular Analysis of LCH: Clonality, Genetics, and Drug Resistance
Cheryl Willman MD
University of New Mexico Cancer Center - Albuquerque, New Mexico USA
Award Amount: $40,000
Grant Awarded in: 1993

Molecular Studies on the Aetiology and Clonality of LCH
George Kannourakis MD, PhD
Royal Children’s Hospital - Victoria, Australia
Award Amount: $40,000
Grant Awarded in: 1993

Mouse Model of Langerhans Cell Histiocytosis
Pieter Leenen PhD (PI); Karel Hahlen MD, PhD; R. Maarten Egeler MD, PhD
Erasmus University - Rotterdam, The Netherlands
Award Amount: $30,000
Grant Awarded in: 2000

Myeloid Dendtritic Cell Developement in Langerhans Cell Histiocytosis
Carl E. Allen MD, PhD; Kenneth L. McClain MD, PhD; Chris Man Tsz-Kwong PhD
Baylor College of Medicine - Houston, Texas USA
Grant Awarded in: 2009

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New Transgenic Mouse Model for Skin LCH: Probing the Disease Mechanisms
Hans Acha-Orbea PhD
University of Lausanne - Epalinges, Switzerland
Grant Awarded in: 2005

Novel Animal Model for LCH
Sergio Lira, MD, PhD
Icahn School of Medicine at Mount Sinai, New York, New York USA
Grant Awarded in: 2014

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Origin of the LCH Cell
Miriam Merad MD, PhD; Matthew Collin MD; Kenneth McClain MD, PhD; Carl Allen MD, PhD
Mount Sinai School of Medicine - New York, New York USA
Grant Awarded in: 2008

Osteopontin Expression and Function in Langerhans Cell Histiocytosis
Carl E. Allen MD, PhD; Tricia L. Peters MD, MS; Kenneth L. McClain MD, Ph
Baylor College of Medicine - Houston, Texas USA
Grant Awarded in: 2009

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Pathogenesis & Biological Behavior of Langerhans Cell Histiocytosis
Wim Timens MD, PhD and Willem A. Kemps MD, PhD
Groningen University Hospital - Groningen, The Netherlands
Award Amount: $7,500
Grant Awarded in: 1992

Pathogenesis & Biological Behavior of Langerhans Cell Histiocytosis: The Role of Cytokines and Cytokine Receptors
Wim Timens MD, PhD
Groningen University Hospital - Groningen, The Netherlands
Award Amount: $5,500
Grant Awarded in: 1994

Possible Viral Etiology of Langerhans Cell Histiocytosis
Kenneth McClain MD, PhD
Texas Children’s Hospital - Houston, Texas USA
Award Amount: $10,000
Grant Awarded in: 1992

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Research Infrastructure for Clinical and Translational Research in Langerhans Cell Histiocytosis (LCH)
Carlos Rodriguez-Galindo MD
Dana-Farber Cancer Institute - Boston, Massachusetts USA
Grant Awarded in: 2012

Role of Apoptosis (Programmed Cell Death) in the Pathogenesis of LCH
Michael Weintraub MD
Hadassah-Hebrew University Medical School - Jerusalem, Israel
Award Amount: $20,000
Grant Awarded in: 1996

Role of BRAF V600E in the Pathogenesis of Langerhans Cell Histiocytosis
Gayane Badalian Very MD, PhD
Dana-Farber Cancer Institute – Boston, Massachusetts USA
Grant Awarded in: 2010

Role of Dectin-1 (Beta Glucan Receptor) in the Interactions of T-cells with Langerhans and Antigen Presenting Cells
Siamon Gordon PhD
Sir Williams Dunn School of Pathology - Oxford, United Kingdom
Total Amount of Award: $30,000
Grant Awarded in: 2002-2004

Role of GM-CSF in the Pathogeny of Langerhans Cell Histiocytosis
Nicole Brousse MD
Hopital Necker Enfants Malades - Paris, France
Award Amount: $10,000
Grant Awarded in: 1994

Role of the Granzyme Inhibitor Proteinase Inhibitor-9 (PI-9) in Langerhans Cell Histiocytosis
Carl F. Classen MD
University Childrens Hospital Rostock - Duisburg, Germany
Grant Awarded in: 2007

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SCID Mouse Model of LCH
Kenneth McClain MD, PhD
Baylor College of Medicine - Houston, Texas USA
Award Amount: $10,000
Grant Awarded in: 1993

Study of Clonality of LCH in Female Patients by Identification of the Inactive X Chromosomes in Single LCH Cells
Jon Pritchard FRCP; Marilyn Monk PhD; Marian Malone FRCP
Hospital for Sick Children - London, United Kingdom
Award Amount: $10,000
Grant Awarded in: 1995

Study of Differentiation and Clonality of Langerhans Cell Precursors in Patients with LCH
Nicole Brousse MD
Hospital Necker Enfants Malades - Paris, France
Award Amount: $20,000
Grant Awarded in: 1999

Study of Dendritic Cell-Derived Multinucleated Giant Cells in Langerhans Cell Histiocytosis
Christine Servet-Delprat PhD
Molecular Immunobiology Clinic; INSERM - Lyon, France
Grant Awarded in: 2005

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Targeted Imaging & Therapy with Humanized Anti-CD1a ScFv Antibody Conjugates for Langerhans Cell Histiocytosis
Robert Arceci MD, PhD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Award Amount: $30,000
Grant Awarded in: 2000

Targeted Imaging and Therapy with Humanized Anti-CD1a Monoclonal Antibody Conjugates for LCH
Robert Arceci MD, PhD
Johns Hopkins - Baltimore, Maryland USA
Total Amount of Award: $60,000 (paid over two years)
$45,000 of total award paid by the Histiocytosis Association of Canada
Grant Awarded in: 2002-2004

T-cell Receptor Vo & Vs Diversity in Langerhans Cell Histiocytsis
Jonna Hvas PhD and George Kannourakis PhD
Royal Children’s Hospital - Victoria, Australia
Award Amount: $10,000
Grant Awarded in: 1995

The Interplay of NOTCH and MAPK Pathway in LCH
Raphaela Schwentner,  MSc, PhD
Children's Cancer Research Institute - Vienna, Austria 
Award Amount: $50,000
Grant Awarded in: 2015

Transgenic Mouse Model Mimicking Abnormal Langerhans Cell Trafficking in Langerhans Cell Histiocytosis
Barrett J. Rollins MD, PhD; Barbara Brandner PhD; Gayane Badalian MD, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Boston, Massachusetts USA
Grant Awarded in: 2007

Transient & Stable Expression of the CD1a Molecule in Human Cell Lines
Raymond Yu MD
Royal Post Graduate Medical School - London, United Kingdom

Award Amount: id="mce_marker"0,000
Grant Awarded in: 1992

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Ultrastructural Studies in Langerhans Cell Histiocytosis: Evidence of Cytological Changes Reflecting Effects of Virus
Gary Mierau PhD
Children’s Hospital of Denver - Denver, Colorado USA
Grant Awarded in: 1992

Unraveling the Pathophysiological Role of the BRAFV600E Mutation in Langerhans Cell Histiocytosis (LCH) and its Therapeutical Implications with Murine Models of High Risk LCH
Miriam Merad, MD, PhD
Icahn School of Medicine at Mount Sinai - New York, New York USA
Grant Awarded in: 2013

Whole Exome Sequencing of Langerhans Cell Histiocytosis
Barrett Rollins MD, PhD; Astrid G.S. van Halteren PhD
Dana-Farber Cancer Institute - Boston, Massachusetts USA
Leiden University Medical Center - Leiden, The Netherlands
Grant Awarded in: 2012

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