HLH/FEL/FHL Grants Awarded

Please click on a letter below to view an alphabetical list of HLH/FEL/FHL Grants awarded by the Histiocytosis Association.

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Accumulation of Heterozygous Mutations on HLH Pathogenesis
Fernando Sepulveda, PhD
Imagine Institute, Paris, France 
Award Amount: $50,000
Grant Awarded in: 2014

Analysis of Gene Expression in HLH Patients Using DNA Microarrays
Janos Sumegi MD
University of Nebraska Medical Center - Omaha, Nebraska USA
Award Amount: $30,000
Grant Awarded in: 2001

Analysis of T-cell Dysfunction in Childhood Hemophagocytic Lymphohistiocytosis
Eiichi Ishii MD, PhD
Hamanomachi Hospital - Fukuoka, Japan
Award Amount: $29,100
Grant Awarded in: 2000

Animal Model of Hemophagocytic Lymphohistiocytosis
Michael Jordan MD
Howard Hughes Medical Institute - Chevy Chase, Maryland USA
Total Amount of Award: $60,000 (paid over two years)
Grant Awarded in: 2002-2004

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Biomarkers in Primary and Secondary Hemophagocytic Lymphohistiocytosis
Janos Sumegi MD, PhD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2011

Biomarker Profiles in Hemophagocytic Diseases - A Systems Biology Approach
E. Marion Schneider PhD
Universitätsklinikum Ulm - Ulm, Germany
Grant Awarded in: 2009

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Chromosomal Localization of the Genetic Lesion in Familial Hemophagocytic Lymphohistiocytosis
Jan-Inge Henter MD, PhD and Gosta Holmgren MD, PhD
Karolinska Hopital - Stockholm, Sweden
Award Amount: $10,000
Grant Awarded in: 1995

Comprehensive mRNA/miRNAs Expression Analysis in Familial Hemophagocytic Lymphohistiocytosis Type 2, Using the C57BL/6-Prf1tm1Sdz/J Murine Model
Janos Sumegi, MD, DSc, PhD
Cincinnati Children's Hospital Medical Center, Cincinnati, OH USA
Grant Awarded in: 2014

Cytotoxic Cell Studies in Family Members of Patients with Hemophagocytic Lymphohistiocytosis (HLH) and Patients with Macrophage Activation Syndrome (MAS)
Alexandra Filipovich MD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Award Amount: $30,000
Grant Awarded in: 2001

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Deciphering the Underlying Molecular Defects in CTL and NK Cell Cytotoxicity in FHL Patients
Claudio Giraudo, PhD
The Children's Hospital of Philadelphia, University of Pennsylvania - Philadelphia, Pennsylvania USA
Award Amount: $50,000
Grant Awarded in: 2015

Defects of Apoptosis as a Cause of Hemophagocytic Lymphohistiocytosis Syndromes
Keith Elkon MD
The Hospital for Special Surgery - New York, New York USA
Award Amount: $50,439
Grant Awarded in: 1995

Defects of Apoptosis as a Cause of Hemophagocytic Lymphohistiocytosis
Keith Elkon MD
Hospital for Special Surgery - New York, New York USA
Award Amount: $49,464
Grant Awarded in: 1997-1998

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Evaluation of the 2B4 Pathway in XLP & HLH
Kim E. Nichols MD
Children’s Hospital of Philadelphia - Philadelphia, Pennsylvania USA
Award Amount: $30,000
Grant Awarded in: 2000

 Focused Screening of Novel Therapies for HLH Using an Animal Model
Michael Jordan MD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2012

Gaining Insights into the Mechanisms of Lymphocyte Cytotoxicity Underlying Hemophagocytic Lymphohistiocytosis
Yenan Bryceson, PhD
Karolinska Institutet, Stockholm, Sweden
Grant Awarded in: 2014 

Ganglioside-Induced Defective Granule Exocytosis-Mediated Cytotoxicity in Hemophagocytic Lymphohistiocytosis
Sasa Radoja PhD
Children's National Medical Center – Washington, District of Columbia USA
Grant Awarded in: 2007

Gangliosides and the Pathogenesis of FEL
Stephan Ladisch MD
Children’s National Medical Center - Washington, District of Columbia USA
Award Amount: $10,000
Grant Awarded in: 1992

Gangliosides and the Pathogenesis of FEL
Ruixiang Li PhD and Stephan Ladisch MD
Children’s National Medical Center - Washington, District of Columbia USA
Award Amount: $10,000
Grant Awarded in: 1993

Gene-Expression Profiling of Peripheral Blood Mononuclear Cells in Hemophagocytic Lymphohistiocytosis
Janos Sumegi MD, DSc, PhD
Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA
Amount Awarded: $47,500
Grant Awarded in: 2010

Gene Therapy in a Mouse Model of Virus-triggered X-linked lymphoproliferative Disease (XLP1):
Control of Infection and Disease Progression

Peter Aichele, PhD
University Medical Center Freiburg, University of Freiburg - Freiburg, Germany
Award Amount: $49,920
Grant Awarded in: 2013

Genetic and Functional Studies on the Pathogenesis of FHL
Jan-Inge Henter MD, PhD (PI) and Bengt Fadeel MD
Karolinska Hopital - Stockholm, Sweden
Award Amount: $30,000
Grant Awarded in: 2001

Genetic Defects in Cytolysis in Patients with Macrophage Activation Syndrome Enrolled in a Clinical Trial to Explore Interleukin-1 Blockage Therapy
Randy Cron, MD, PhD
University of Alabama at Birmingham - Birmingham, AL USA
Award Amount: $50,000
Grant Awarded in: 2016

Genetic Dissection of the Exocytic Machinery in Cytotoxic Lymphocytes
Matthias Voss,  PhD
Karolinska Institutet - Stockholm, Sweden
Award Amount: $50,000
Grant Awarded in: 2015

Genetic Mapping in Familial Haemophagocytic Lymphohistiocytosis
D. Mark Layton and Michel R.A. Lalloz PhD
King’s College - London, United Kingdom
Award Amount: $19,960
Grant Awarded in: 1999

Genetic Marker for FHL
Jan-Inge Henter MD, PhD
Karolinska Hopital - Stockholm, Sweden
Award Amount: $10,000
Grant Awarded in: 1992

Genetic Studies on the Pathogenesis of FHL
Magnus Nordenskjöld MD, PhD
Karolinska University Hospital - Stockholm, Sweden
Grant Awarded in: 2006

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HIF-1α Signaling is a Central Pathobiologic Mediator of Hemophagocytic Lymphohistiocytosis
Gang Huang, PhD
Children’s Hospital Medical Center - Cincinnati, OH USA
Award Amount: $50,000
Grant Awarded in: 2016

Histiocytosis and Familial Erythrophagocytic Lymphohistiocytosis (FEL) Research
Diane Komp MD and Joel Rappeport MD
Yale Medical School - New Haven, Connecticut USA
Award Amount: $30,000
Grant Awarded in: 1995

HLH Clinical Trial/ NK Cell Activity
Jan-Inge Henter MD, PhD
Karolinska Hopital - Stockholm, Sweden
Award Amount: $2,000
Grant Awarded in: 1995

HLH-94 Clinical Trial
Jan-Inge Henter MD, PhD
Karolinska Hopital - Stockholm, Sweden
Award Amount: $25,000
Grant Awarded in: 2000

HLH-94 Clinical Trial
Jan-Inge Henter MD, PhD
Karolinska Hopital - Stockholm, Sweden
Total Amount of Award: $15,000
Grant Awarded in: 2002-2004

Homozygozity Mapping for Identification of a Novel Genetic Defect in Patients with
Familial Hemphogocytic Lymphohistiocytosis

Udo zur Stadt MD
University Medical Center Hamburg Eppendorf - Hamburg, Germany
Grant Awarded in: 2006

Homozygosity Mapping to Reveal Novel Genetic Defects in Patients with Familial Hemophagocytic Lymphohistiocytosis
Maurizio Aricò MD
Osoedale dei Bambini "G. Di Cristina" - Palermo, Italy
Grant Awarded in: 2006

Hybrid ImmunoTherapy (ATG/Dexamethasone/Etoposide) for Hemophagocytic Lymphohistiocytosis: The HIT-HLH Trial
Michael Jordan MD
Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA
Grant Awarded in: 2010

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Identification of Lytic Granule Exocytosis-Related Candidate Genes Involved in Pathogenesis of
Hemophagocytic Lymphohistiocytosis

Sasa Radoja PhD and E. Marion Schneider PhD
Children's Research Institute - Washington, District of Columbia USA
Grant Awarded in: 2005

Identification of Molecular Mechanisms Underlying Defective Cytotoxic Lymphocyte Function in Chediak-Higashi Syndrome, a Histiocytic Lysosomal Storage Disorder with Immunodeficiency
Konrad Krzewski, PhD
National Institute of Allergy and Infectious Diseases, National Institutes of Health - Rockville, Maryland USA 
Award Amount: $50,000
Grant Awarded in: 2015

Immune Function Studies in Family Members of Patients with Hemophagocytic Lymphohistiocytosis
Alexandra Filipovich MD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Award Amount: $19,923
Grant Awarded in: 1999

Improving Diagnostics of and Gaining Mechanistic Insights into Defects in Lymphocyte Cytotoxicity Underlying HLH
Yenan Bryceson PhD
Karolinska Institutet Center for Infectious Medicine - Stockholm, Sweden
Grant Awarded in:2012

Interrogating Disease Mechanisms in a Novel Mouse Model of Hemophagocytosis
Michelle Hermiston MD, PhD
University of California, San Francisco - San Francisco, California USA
Grant Awarded in: 2008

Investigations into the Clinical and Molecular Pathogenesis of XIAP Deficiency
Rebecca Marsh MD; Jack J. H. Bleesing MD, PhD; Kimberly Risma MD, PhD; 
Lisa Filipovich MD
Cincinnati Children's Hospital Medical Center – Cincinnati, Ohio USA
Grant Awarded in: 2007

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Janus Kinase Inhibition as a Novel Treatment for Hemophagocytic Lymphohistiocytosis

Kim E. Nichols, MD
The Children's Hospital of Philadelphia - Philadelphia, Pennsylvania USA
Grant Awarded in: 2013

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M1 Versus M2 Polarization of the Hemophagocyte: Insight into Biologic Function
Edward Behrens MD
The Children's Hospital of Philadelphia - Philadelphia, Pennsylvania, USA
Grant Awarded in: 2012

Mechanisms of Interferon Gamma-Induced Hemophagocytosis
Michael Jordan MD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2008

Mechanistic Studies of Defects in Lymphocyte Cytotoxicity Underlying HLH
Yenan Bryceson PhD
Center for Infectious Medicine – Stockholm, Sweden
Grant Awarded in: 2010

Mechanistic Studies of Defects in Lymphocyte Cytotoxicity Underlying HLH
Yenan Bryceson PhD
Karolinska Institutet Center for Infectious Medicine - Stockholm, Sweden
Grant Awarded in: 2011

Molecular Basis of NK Cell Dysfunction in Familial Haemophagocytic Lymphohistiocytosis
E. Marion Schneider PhD
University of Dusseldorf - Dusseldorf, Germany
Award Amount: $9,065
Grant Awarded in: 1995

Novel Photoconvertable Florescent Proteins to Trace Hemophagocytes in Whole Blood
Marion Schneider PhD
University of Ulm - Ulm, Germany
Grant Awarded in: 2005

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Pathogenesis of XLP Due to XIAP Deficiency
Rebecca A. Marsh MD; Jack J. H. Bleesing MD, PhD; Alexandra Filipovich MD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2008

Perforin Gene Transfer into Human Cytotoxic Lymphocytes
Kimberly Risma MD, PhD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2011

Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic Function
Kimberly Risma MD, PhD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2009

Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic Function
Kimberly Risma MD, PhD
Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio USA
Grant Awarded in: 2010

Proteolytic Maturation of Perforin: Determining the Requirements for Cytotoxic Function
in Patients with Hemophagocytic Lymphohistiocytosis

Kimberly Risma MD, PhD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2008

Revised International Treatment Protocol for HLH-94 Clinical Trial
Jan-Inge Henter MD, PhD
Astrid Lindgren Children's Hospital - Stockholm, Sweden
Award Amount: $30,000
Grant Awarded in: 2001

Revisiting the Candidate Regions for Familial Hemophagocytic Lymphohistiocytosis (FHLH):
Loss-of-Function-Screening Search for the Missing Disease Causing Genes

Janos Sumegi MD, PhD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2008

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Structure/Function Relationships in the MUNC13-4 Protein: Molecular Consequences of Familial Hemophagocytic Lymphohistiocytosis Associated Mutations
Janos Sumegi MD
Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio USA
Grant Awarded in: 2006

Study of the Genetic Defects Underlying HLH: Investigation of Cellular Abnormalities Associated with
Defective NK Cell Function and Resultant Dysregulation of T-cell Populations
Alexandra Filipovich MD
Cincinnati Children’s Hospital Medical Center - Cincinnati, Ohio USA
Total Amount of Award: $60,000 (paid over two years)
Total amount paid by the Histiocytosis Association of Canada
Grant Awarded in: 2002-2004

Studies on Cytokines, Clonality & Apoptosis in HLH Cells
Shinsaku Imashuku MD
Kyoto City Institute of Health & Environmental Science - Kyoto, Japan
Award Amount: $10,000
Grant Awarded in: 1994

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The use of a newly generated murine model to determine the broad role of STXBP2 in FHL5 pathogenesis
Fernando Sepulveda, PhD
Imagine Institute - Paris, France
Award Amount: $50,000
Grant Awarded in: 2016

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